I've always though it's about Em falling appart from the group when he became big and famous. He is like:
You ran the streets I nine to fived it,
We grew up, grew apart as time went by us,
Then I blew up to both yours and mine surprises
And Proof is like:
and every time I go to hear you play you look away
we barely embrace, you can't even look me in my face
It's all so obvious!